When isolated from clinical specimens, nondiphtherial Corynebacteria, such as Corynebacterium striatum, Corynebacterium amycolatum. ABSTRACT. We describe an unusual cluster of Corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (COPD) admitted. Objective: To evaluate the clinical significance of and describe factors associated with Corynebacterium striatum infection. Methods: A.

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As expected, the 10 C. Multiple drug resistance is caused by the interplay of multiple ckrynebacterium mechanisms those emerge via the acquisition of extraneous resistance determinants or spontaneous mutations.

Corynebacterium striatum: a diphtheroid with pathogenic potential.

Twenty out of the 24 C. Published online Aug Additionally, 16 conserved signature proteins, which are uniquely found in Corynebacterium species, have been identified. Gaiellales Rubrobacterales Thermoleophilales Solirubrobacterales.

When isolated from clinical specimens, nondiphtherial Corynebacteriasuch as Corynebacterium striatumCorynebacterium amycolatumCorynebacterium minutissimumCorynebacterium xerosisand Corynebacterium freneyiwere originally thought to be contaminants [ 2 ], as these strains are commonly considered as part of the normal flora of human skin and mucous membranes.

One of the most studied species is C. PFGE patterns and antibiotic resistance profiles of the 63 C. Campanile F, et al. This is a report of an unusual case of wound infection in a patient with laryngeal carcinoma. The Microbial Production of Amino Acids. The anatomical sites of specimens from whom the 63 C. Our results confirmed those of previous studies which pointed out that erm X is the most important gene implicated in MLS resistance in Corynebacterium spp 29 In the present case, we report a catheter-related bloodstream infection caused by C.

However, this gene was also detected in strains susceptible to kanamycin, probably due to mutations affecting its coding sequence or its promoter. Received Feb 7; Accepted Aug 4.

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Corynebacterium diphtheriae Diphtheria Corynebacterium minutissimum Erythrasma Corynebacterium jeikeium Group JK corynebacterium sepsis. Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM isolated from blood samples of a leukemia patient.

However, most of these cases are represented by patients with implanted indwelling devices or who present an immunosuppression [ 26 ]. Corynebacteria grow slowly, even on enriched media. Tauch A, et al. Medically relevant Corynebacterium species include Corynebacterium diphtheriaethe primary cause of diphtheria, and the non-diphtherial corynebacteria, which are part of the normal flora of the skin and mucous membranes.

Journal of Applied Bacteriology. In Ford, Marvella E.

Antimicrobial susceptibility assays Antimicrobial susceptibilities were determined by micro-dilution in cation adjusted Muller-Hinton broth and interpreted following Clinical and Laboratory Standards Institute CLSI guidelines Nondiphtherial corynebacteria have been frequently dismissed as a contaminant when isolated from clinical materials.

Resistance to fluoroquinolones in Corynebacterium spp. Fluoroquinolones have been intensively used at the FHU hospital during the last two decades. Isolates were classified as resistant, intermediate, or susceptible, according to criteria defined by CLSI In two strains no changes in their QRDRs were detected, indicating that resistance was mediated by a different mechanism.

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The mef A-E gene was not found in any strain tested. Gram-positive bacilli were detected in corynehacterium blood culture samples; each set included aerobic and anaerobic cultures Figures 1 b and 1 c.

Unfortunately, we could not successfully treat the patient because of her poor general condition and comorbidity. Written informed consent was obtained from each patient from whom samples were taken. Transpl Infect Dis ;5: Upon antibiotic administration, a selective pressure is corynebcaterium in body organs where fluoroquinolones tend to accumulate. Introduction The Corynebacteria are a group of aerobic, Gram-positive, catalase-positive, nonsporulating, generally nonmotile rods [ 1 ].

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Multidrug-resistant Corynebacterium striatum bacteremia: Based on studies of 16S- rRNAthey have been grouped into the subdivision of gram-positive eubacteria with high G: Three of the conserved signature proteins have homologs found in the genus Dietziawhich is believed to be the closest related genus to Corynebacterium. The fact that many different antibiotic resistance profiles could be distinguished among the strains belonging to a particular PFGE pattern revealed that there was not a single strain but several closely related clones producing sporadic infections.

Relationship between mutations in the gyrA gene and quinolone resistance in corynebacteroum isolates of Corynebacterium striatum and Corynebacterium amycolatum. This cluster is distinguished by several conserved signature indels, such as a two-amino-acid insertion in LepA and a seven- or eight-amino-acid insertions in RpoC. How to cite this URL: National Center for Biotechnology InformationU. Structure, Function, and Genetics.

Corynebacterium striatum Bacteremia Associated with a Catheter-Related Blood Stream Infection

Therefore, in this case, appropriate antibiotics could not be judged in vivo. Eight MDR isolates showed resistance to eight or more compounds, belonging to seven main classes of antibiotics aminoglycosides, ansamycins, macrolides, lincosamides, fluoroquinolones, penicillins and cephalosporins.

Actinomyces israelii Actinomycosis Cutaneous actinomycosis Tropheryma whipplei Whipple’s disease Arcanobacterium haemolyticum Arcanobacterium haemolyticum infection Actinomyces gerencseriae. However, the occurrence of resistant strains requires continual vigilance. The corynebaterium of the QRDR region of the gyrA gene of 21 isolates categorized as resistant or intermediate corynebactwrium fluoroquinolones were compared to that of the quinolone-susceptible C.

A spontaneous joint infection with Corynebacterium striatum. Corynebacterium species occur commonly in nature in the soil, water, plants, and food products.